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2011•Practical Journal of Medicine & PharmacyRequires access

Influence of tirofiban on the TIMI flow of patients with acute STEMI before primary PCI

Wei Yun-liang

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Abstract

Objective To study TIMI(thrombolysis in myocardial infarction) flow influence of GPⅡb/Ⅲa receptor antagonists(tirofiban) in patients with acute STEMI before primary PCI.Methods The thirty-six STEMI patients(meanage 46.2±8.6 years old) admitted during Sept,2008 to July,2010 were included in the study.The patients were divided into the primary PCI group(n=17) and primary PCI plus tirofiban group(n=19).Changes in TIMI flow were observed during the operation.Results The incidence of slow flow and no reflow of tirofiban+PCI group was lower than that of the primary PCIgroup(3.75% vs 18.12%,P0.05);and embolism of distal IRA was all lower than that of the primary PCI group during operation(0% vs 15.78%,P0.05).Conclusion Tirofiban injection before primary PCI in patients with STEMI is feasible and can reduce the rate of no reflow during operation.

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Objective To study TIMI(thrombolysis in myocardial infarction) flow influence of GPⅡb/Ⅲa receptor antagonists(tirofiban) in patients with acute STEMI before primary PCI.Methods The thirty-six STEMI patients(meanage 46.2±8.6 years old) admitted during Sept,2008 to July,2010 were included in the study.The patients were divided into the primary PCI group(n=17) and primary PCI plus tirofiban group(n=19).Changes in TIMI flow were observed during the operation.Results The incidence of slow flow and no reflow of tirofiban+PCI group was lower than that of the primary PCIgroup(3.75% vs 18.12%,P0.05);and embolism of distal IRA was all lower than that of the primary PCI group during operation(0% vs 15.78%,P0.05).Conclusion Tirofiban injection before primary PCI in patients with STEMI is feasible and can reduce the rate of no reflow during operation.

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Available abstract

Objective To study TIMI(thrombolysis in myocardial infarction) flow influence of GPⅡb/Ⅲa receptor antagonists(tirofiban) in patients with acute STEMI before primary PCI.Methods The thirty-six STEMI patients(meanage 46.2±8.6 years old) admitted during Sept,2008 to July,2010 were included in the study.The patients were divided into the primary PCI group(n=17) and primary PCI plus tirofiban group(n=19).Changes in TIMI flow were observed during the operation.Results The incidence of slow flow and no reflow of tirofiban+PCI group was lower than that of the primary PCIgroup(3.75% vs 18.12%,P0.05);and embolism of distal IRA was all lower than that of the primary PCI group during operation(0% vs 15.78%,P0.05).Conclusion Tirofiban injection before primary PCI in patients with STEMI is feasible and can reduce the rate of no reflow during operation.

Key concepts: Tirofiban, Conventional PCI, TIMI, Medicine, Thrombolysis, Cardiology, Internal medicine, Myocardial infarction

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