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2001•Journal of Qilu OncologyRequires access

Relationship Between p53 Protein and P-glycoprotein Expression in Breast Cancer

Yan Wang

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Abstract

Objective To study the relationship between p53 protein and P glycoprotein(P gp)expression in breast cancer tissues.Methods 50 breast cancer specimens were examined for p53 protein and P gp by immunohistochemical methods.Results The positive rate of p53 expression is 64%,of P gp is 50%.In p53 positive groups,the levels of P gp expression (65.6%)is significantly higher than(22.2%) p53 negative groups,( P 0.005 ).Conclusions Mutation of p53 gene may result in high expression of MDR1 gene;High expression of P gp can not be used as a predictor of prognosis and biological behavior in breast cancer.

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Objective To study the relationship between p53 protein and P glycoprotein(P gp)expression in breast cancer tissues.Methods 50 breast cancer specimens were examined for p53 protein and P gp by immunohistochemical methods.Results The positive rate of p53 expression is 64%,of P gp is 50%.In p53 positive groups,the levels of P gp expression (65.6%)is significantly higher than(22.2%) p53 negative groups,( P 0.005 ).Conclusions Mutation of p53 gene may result in high expression of MDR1 gene;High expression of P gp can not be used as a predictor of prognosis and biological behavior in breast cancer.

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Available abstract

Objective To study the relationship between p53 protein and P glycoprotein(P gp)expression in breast cancer tissues.Methods 50 breast cancer specimens were examined for p53 protein and P gp by immunohistochemical methods.Results The positive rate of p53 expression is 64%,of P gp is 50%.In p53 positive groups,the levels of P gp expression (65.6%)is significantly higher than(22.2%) p53 negative groups,( P 0.005 ).Conclusions Mutation of p53 gene may result in high expression of MDR1 gene;High expression of P gp can not be used as a predictor of prognosis and biological behavior in breast cancer.

Key concepts: Immunohistochemistry, Breast cancer, P53 protein, P53 expression, P-glycoprotein, Cancer research, Glycoprotein, Gene

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