Resistance of 96 strains of streptococcus pneumoniae in children

Objective To investigate antibiotic resistance of streptococcus pneumoniae to children in Nanjing.Methods Totally 96 strains of streptococcus pneumoniae were collected to test the MICs of various antibiotics by agar dilution method according to the approved standard of CLIS.Results Among 96 strains of streptococcus pneumoniae,63(65.6%) strains were resistant to penicillin(MIC≥2 mg/L).87.5%,29.2%,8.3% and 4.2% of streptococcus pneumoniae were resistant against the cefuroxime,cefotaxim,amoxicillin,and ceftriaxone,retrospectively.The resistance rates to other antibiotic agents,such as erythromycin,azithromycin,tetracycline,and Chloram-phenicol were 96.9%,95.8%,95.8%,94.8%,respectively.All 96 strains of streptococcus pneumoniae were sensitive to vancomycin,tigecycline and linezolid.Conclusion The antibiotic resistance to streptococcus pneumoniae is serious in Nanjing.Most of them are multi-resistant strains.Except for vancomycin,tigecycline,linezolid,and ceftriaxone,most antibiotic agents have lost the reactivities against streptococcus pneumoniae.