Analysis of the expressions of HER-2 and NFκB/p65 in human epithelial ovarian tumor

Objective To investigate the expressions of HER-2 and NFκB/p65 in human epithelial ovarian tumor and discuss its clinical significance.Methods The expressions of HER-2 and NFκB/p65 in 63 specimens of ovaries were detected by immunohistochemistry method.The samples included 7 specimens of normal ovaries,10 specimens of benign ovarian tumors,10 specimens of borderline ovarian tumors,and 36 specimens of ovarian epithelial cancers.Results The positive rates of the expression of HER-2 in benign ovarian tumors,borderline ovarian tumors,and ovarian epithelial cancers were 10.0%,30.0%,36.1%(P0.05).The positive rates of the expression of NFκB/p65 in benign ovarian tumors,borderline ovarian tumors,and ovarian epithelial cancers were 20.0%,50.0%,75.0%(P0.05).There was no expression of HER-2 and NFκB/p65 in normal ovaries.The positive rate of HER-2 in ovarian epithelial cancer was related with pathological grade,the positive rate was higher if the tissues were poor differentiated(P0.05).The expression of HER-2 in ovarian epithelial cancer was not related with histotype,clinical stage,ascites,and age.The expression of NFκB/p65 in ovarian epithelial cancer was not related with pathological grade,histotype,clinical stage,ascites,and age.There was no relationship between the expression of HER-2 and NFκB/p65 in ovarian epithelial cancers.Conclusion HER-2 could be considered as one of the prognostic target of ovarian epithelial cancer.NFκB/p65 might contribute to the process of the development of ovarian epithelial tumor.HER-2 might not be effect on the process of gene activation and expression of NFκB/p65,or it is just one of the influencing factors,but not the independent one.