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The Preventive and Therapeutic Effect of Jiaweibiejiajian Pill on Rats with Hepatic Fibrosis Induced by Serum Albumin

Song Chong-shun

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Abstract

Objective:To study the preventive and therapeutic effect of Chinese medicine Jiaweibiejiajian Pill(JWBJ)on rats with hepatic fibrosis induced by human serum albumin.Methods:The rats model with hepatic fibrosis was induced by multiple subcutaneous injections of serum albumin solution for 4 times.After it was confirmed that there were albumin antibody in rats serum,and then rats were divided into model-group,low-dose group of JWBJ,mediate-dose group of JWBJ and high-dose group of JWBJ.Rats were given JWBJ orally every day,and injected albumin solution into the rats caudal veins for 9 times during 4 weeks.When hepatic fibrosis was verified to come into being by pathological examination.Alanine amino transaminase(ALT),aspartate aminotranferase(AST),total protein(TP),albumin(ALB) Hyaluronic acid(HA),Laminin(LN),Collagen Type(PC) in serum of all rats were examined.Results:Compared with the model group,JWBJ could obviously decrease the concentration of serum ALT,AST,HA,LN,CIV and increase the concentration of serum ALB,TP,and increase the ratio of serum A/G of rats with hepatic fibrosis,and reduce the degree of hepatic fibrosis.Conclusion:JWBJ can effectively prevent and treat hepatic fibrosis induced by serum albumin.

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Objective:To study the preventive and therapeutic effect of Chinese medicine Jiaweibiejiajian Pill(JWBJ)on rats with hepatic fibrosis induced by human serum albumin.Methods:The rats model with hepatic fibrosis was induced by multiple subcutaneous injections of serum albumin solution for 4 times.After it was confirmed that there were albumin antibody in rats serum,and then rats were divided into model-group,low-dose group of JWBJ,mediate-dose group of JWBJ and high-dose group of JWBJ.Rats were given JWBJ orally every day,and injected albumin solution into the rats caudal veins for 9 times during 4 weeks.When hepatic fibrosis was verified to come into being by pathological examination.Alanine amino transaminase(ALT),aspartate aminotranferase(AST),total protein(TP),albumin(ALB) Hyaluronic acid(HA),Laminin(LN),Collagen Type(PC) in serum of all rats were examined.Results:Compared with the model group,JWBJ could obviously decrease the concentration of serum ALT,AST,HA,LN,CIV and increase the concentration of serum ALB,TP,and increase the ratio of serum A/G of rats with hepatic fibrosis,and reduce the degree of hepatic fibrosis.Conclusion:JWBJ can effectively prevent and treat hepatic fibrosis induced by serum albumin.

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Available abstract

Objective:To study the preventive and therapeutic effect of Chinese medicine Jiaweibiejiajian Pill(JWBJ)on rats with hepatic fibrosis induced by human serum albumin.Methods:The rats model with hepatic fibrosis was induced by multiple subcutaneous injections of serum albumin solution for 4 times.After it was confirmed that there were albumin antibody in rats serum,and then rats were divided into model-group,low-dose group of JWBJ,mediate-dose group of JWBJ and high-dose group of JWBJ.Rats were given JWBJ orally every day,and injected albumin solution into the rats caudal veins for 9 times during 4 weeks.When hepatic fibrosis was verified to come into being by pathological examination.Alanine amino transaminase(ALT),aspartate aminotranferase(AST),total protein(TP),albumin(ALB) Hyaluronic acid(HA),Laminin(LN),Collagen Type(PC) in serum of all rats were examined.Results:Compared with the model group,JWBJ could obviously decrease the concentration of serum ALT,AST,HA,LN,CIV and increase the concentration of serum ALB,TP,and increase the ratio of serum A/G of rats with hepatic fibrosis,and reduce the degree of hepatic fibrosis.Conclusion:JWBJ can effectively prevent and treat hepatic fibrosis induced by serum albumin.

Key concepts: Hepatic fibrosis, Albumin, Medicine, Internal medicine, Serum albumin, Fibrosis, Endocrinology, Therapeutic effect

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The Preventive and Therapeutic Effect of Jiaweibiejiajian Pill on Rats with Hepatic Fibrosis Induced by Serum Albumin — Research Paper | ScholarLens