Therapeutic effects of human dermal papilla cells conditioned medium on alopecia areata

Objective To observe the therapeutical effects of human dermal papilla cells(DPC) conditioned medium on alopecia areata, to probe the active molecules that can promote hair follicle growth excreted by human dermal papilla cells. Methods Collected conditioned medium from lower passage human dermal papilla cells and prepared for freeze drying powder, and use it to treat 50 patients with alopecia areata subcutaneously. Among them 26 cases were chosen for the triamcinolone group and 10 cases for the control group. Results The cure rates were 74%, 54% and 10% in the DPC conditioned medium group, the triamcinolone group and the control group respectively, the total effective rates were 96%, 73% and 30% respectively. Both the cure rate and the total effective rate of the DPC conditioned medium group were higher than those in the triamcinolone group and the control group(P0.01). Conclusion The human dermal papilla cells conditioned medium can promote alopecia areata hair follicle growth in vivo.