Relationship between Resistin and Insulin Resistance,Obesity and Type 2 Diabetes

Over the past decade,resistin,as a novel adipokine,is regarded to link insulin resistance,obesity and type 2 diabetes.Many studies on rodents showed that resistin caused insulin resistance in mice and was associated with obesity and diabetes.However,the role of resistin in human disease remains controversial.The physiological functions of resistin are unknown at present.On the other hand,current evidence appears to suggest that resistin is a kind of proinflammatory cytokine.This article reviewed the relationships among resistin,insulin resistance,obesity and type 2 diabetes.