The Efficacy of Insulin Glargine Combined with Acarbose in Patients with Fluctuating High Blood Glucose

Objective To study on the efficacy and safety of insulin glargine combined with acarbose in elderly patients newly diagnosed type 2 diabetic mellitus with fluctuating high blood glucose. Methods 30 of patients with fluctuating high blood glucose were selected and given insulin glargine combined with acarbose besides diet control for three months, and their fluctuation of blood glucose was observed at the beginning and the end of the study. Results HbA1C, MBG, SDBG, MAGE and MODD were significantly lower at the beginning than at the end[7.37%±0.47% vs 8.29%±0.73%, (8.04±2.25) vs (10.06±2.48) mmol/L, (1.52±0.35) vs ( 2.36±0.53) mmol/L, (4.40±1.02) vs (5.64±1.22) mmol/L, (1.26±0.49) vs (1.72±0.60) mmol/L, respectively; P0.05 or P0.01]. Conclusion It might be more effective and safer for elderly patients with type 2 diabetic mellitus to use insulin glargine combined with acarbose in controlling level and fluctuation of blood sugar.