An experimental research on protective effect of compound injection salvia miltiorrhiza for damage of retinal ischemia reperfusion in rat retinopathy

Objective To investigate the protective effect of compound injection salvia miltiorrhiza in retinal ischemia reperfusion(RIR).Methods To increase the intraocular pressure and infuse anterior chambers with liquid so as to induce the models of retinal ischemia reperfusion of rats,which were then randomly divided into defence group and control group.A vein injection of compound injection salvia miltiorrhiza was performed at a dose of 0.05 ml at 30 min before retinal ischemia in the defence group and normal saline 0.05 ml in the control group.30 minutes,24 hours and 72 hours after ischemia reperfusion,the content of malandialdehyde(MDA) in rat retinas were measured and histopathologic changes were observed with transmission electron microscopy and light microscopy.Results 30 minutes,24 hours and 72 hours after ischemia reperfusion,the content of MDA in rat retinas in defence group was significantly less than that in control group(P0.01).The histopathologic injury of retina in the control group was less than that in the defence group.Conclusion Injection of salvia miltiorrhiza composite is an effective protection method for retinal ischemia reperfusion induced retinopathy.