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2005•The Journal of Pharmaceutical PracticeRequires access

Study on the model of gastric mucosal precancerous lesion in rat

Junshan Ruan

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Abstract

Objective: To establish a practical and effective animal model in order to study gastric mucosal precancerous lesion (GPL) in rat. Methods: Three group were classified in the experimental. Normal group: not to establish the model; Model group Ⅰ established the model only use N-methyl-N ' -nitro-N ' -nitrosoguanididne (MNNG) . Model group Ⅱ: established the model by com-plexed method such as the diet, N-methyl-N' -nirtro-N-nitrosoguanidine( MNNG) , alcohol, ranitidine and so on. The change of GPL in pathohistologic were observed. Results: Experimental GPL of rats were induced successfully. Conclusion: It was found that the rate of GPL in model group Ⅱ is higher than that in model group Ⅰ. And the established time was only 20 weeks which was less than 35 weeks that have ever reproted. The model is a practical and effective animal model in studying on GPL in rat.

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What this paper is about

Objective: To establish a practical and effective animal model in order to study gastric mucosal precancerous lesion (GPL) in rat. Methods: Three group were classified in the experimental. Normal group: not to establish the model; Model group Ⅰ established the model only use N-methyl-N ' -nitro-N ' -nitrosoguanididne (MNNG) . Model group Ⅱ: established the model by com-plexed method such as the diet, N-methyl-N' -nirtro-N-nitrosoguanidine( MNNG) , alcohol, ranitidine and so on. The change of GPL in pathohistologic were observed. Results: Experimental GPL of rats were induced successfully. Conclusion: It was found that the rate of GPL in model group Ⅱ is higher than that in model group Ⅰ. And the established time was only 20 weeks which was less than 35 weeks that have ever reproted. The model is a practical and effective animal model in studying on GPL in rat.

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Available abstract

Objective: To establish a practical and effective animal model in order to study gastric mucosal precancerous lesion (GPL) in rat. Methods: Three group were classified in the experimental. Normal group: not to establish the model; Model group Ⅰ established the model only use N-methyl-N ' -nitro-N ' -nitrosoguanididne (MNNG) . Model group Ⅱ: established the model by com-plexed method such as the diet, N-methyl-N' -nirtro-N-nitrosoguanidine( MNNG) , alcohol, ranitidine and so on. The change of GPL in pathohistologic were observed. Results: Experimental GPL of rats were induced successfully. Conclusion: It was found that the rate of GPL in model group Ⅱ is higher than that in model group Ⅰ. And the established time was only 20 weeks which was less than 35 weeks that have ever reproted. The model is a practical and effective animal model in studying on GPL in rat.

Key concepts: Animal model, Precancerous lesion, Rat model, Normal group, Experimental animal, Lesion, Internal medicine, Gastroenterology

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