Effect of early intensive atorvastatin treatment on serum adiponectin and blood lipid level in patients with acute coronary syndrome.

Objective To study the effect of early intensive atorvastatin treatment for acute coronary syndrome. Methods Ninety-six patients of acute coronary artery in our hospital were randomly divided into the study group and the control group, with 48 cases in each group. Patients in the study group received atorvastatin 40 mg/d, and patients in the control group received atorvastatin 10 mg/d, both for 1 month. The blood lipid, serum adiponectin(APN), and high sensitivity C reactive protein(hs-CRP) levels were observed before treatment, and 24 h, 72 h, 1 week and 1 month after treatment. The incidence of cardiovascular events and adverse drug reactions were observed during the follow-up of 6 months. Results Before treatment, the two groups showed no statistically significant difference in total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), APN and hs-CRP levels(P0.05). 72 h after treatment, the APN levels of two group was significantly higher than before treatment, the level of hs-CRP was significantly lower(P0.05), and the level of LDL-C were significantly lower(P0.05). 72 h, 1 week, 1 month after treatment, serum APN of the study group was significantly higher than that of the control group, the level of hs-CRP was significantly lower than the control group(P0.05). One month after treatment, the LDL-C, TC levels were significantly lower in the study group than the control group(P 0.05). The incidence of cardiovascular events in the study group was significantly lower than the control group(P 0.01). There were no serious adverse reactions in the two groups during the follow-up. Conclusion Early intensive atorvastatin therapy can effectively decrease the blood lipid levels, and reduce the incidence of cardiovascular events. The effects may be related to the fact that atorvastatin increases serum adiponectin levels and reduces inflammation.