Study on Preparation Technique and Quality Control of Ziwan Zhike Dropping Pills

Objective:To establish the optimized preparation procedure and study the method to control the quality of Ziwan Zhike dropping pills.Method: The preparation conditions,such as the proportion between the extracts(ZDE) and PEG,the temperature,dropping distance were studied with orthogonal test.The content of total flavonoids and saponins was determined by ultraviolet spectrophotometry method.Result:The optimized preparation process was as follows: PEG4000-PEG6000(1∶1) was optimal base,ratio between ZDE and base was 1∶2.5,the temperature of drug solution was 70 ℃,the dropping distance was 4cm.Three batches of the prepared products meet the standards of Chinese Pharmacopoeia on dropping pills.The content of total flavonoids and saponins of Ziwan Zhike dropping pills was 14.15% and 3.091% respectively.The average recovery was 98.90% and 100.06%.Conclusion: The preparation procedure is feasible,simple and suitable.The method eatablished in this paper can be adopted for the quality control of Ziwan Zhike dropping pills,and the determination method is simple,relatively fast and accurate.