2003•Acta Medicinae SinicaRequires access
The Clinical Significance of P16 Protein Expression in Breast Carcinoma
Wu Jian
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Abstract
Objective:To investigate the correlation of P16 protein expression in breast carcinoma with clinical stage.Methods:The expression of P16 protein was detected in 30 cases of breast carcinoma, 20 cases of breast fibroadenoma and 20 cases of normal breast tissue by immunohistochemistry.Results:The positive rate of P16 protein expression was 46.6% in breast carcinoma,80% in breast fibroadenoma,85% in normal breast tissue.There was significant difference of positive rate among these three groups ( P 0.05).Conclusion:The abnormal P16 protein expression plays an important role in development of breast carcinoma.There is remarkable correlation of abnormal P16 protein expression with clinical stage.