Effect of carvedilol on plasma ET-1 and CGRP in the congestive heart failure patients

Objective To study the effect of carvedilol on plasma ET-1 and calcitonin gene related peptide(CGRP) in the congestive heart failure patients.Method Sixty congestive heart failure patients were divided into two groups:the carvedilol group and the conventional treatment group.The changes in plasma levels of ET-1 and CGRP in the two groups before and after 6 months of taking the drug were measured and compared with the normal control group.Results The plasma ET-1 of the congestive heart failure patients was higher remarkably than that of the normal control group (P0.01). The plasma CGRP was lower than that of the normal control group(P0.05). After the carvedilol treatment the plasma ET-1 was lower remarkably and the plasma CGRP was higher remarkably than those before treatment(P0.01).After treatment the plasma ET-1 and CGRP of the conventional treatment group exhibited no significant change.Conclusion In this study, the plasma ET-1 was reduced and the plasma CGRP was increased by carvedilol in the congestive heart failure patient.