Analysis of distribution and drug reisitance of pathogens in ICU

Objective To analyze the bacterial distribution and resistance of pathogens isolated from infection patients in intensive care unit(ICU). Methods A total of 528 strains was isolated from all kinds of clinical specimens of patients in ICU from January to December of 2010.Pathogens were indentifid by France bioMerieux vitekII automatic bacterial identification system.K-B tests were conducted to detect drug sensitivity. WHONET 5.6 was applied to analyze the bacterial distribution and drug resistance. Results Gram-negative strains accounted for 80.3% in 528 isolated strains of pathogenic bacteria.Gram-positive strains accounted for 12.7% and fungi accounted for 7%. The top 1 bacteria was Paeudomonas aeruginosa(26.1%),which was followed by Acinetobacter baumannii(24.2%),Escherichia coli(5.5%),and Klebsiella pneumoniae(5.3%).The resistance rates of Paeudomonas aeruginosa and Acinetobacter baumannii to all the antimicrobial agents were greater than 70.0% and 78.0%(except for cefoperazone/sulbactam and minocyline).The resistance rate of Enterbacteriaceae to cephalosporins was greater than 55.0%.The resistance rates of Enterbacteriaceae to imipenem and meropenem were 11.2% and 10.1%,respectively. Conclusion The main pathogens in ICU were Gram-negative strains,which were highly resistant to many kinds of antimicrobial agents.