Expression of PEG10 in human hepatocellular carcinoma and its clinical significance

Objective To investigate the expression of PEG10 as HCC cell marker in human hepatocellular carcinoma tissues and its clinical significance.Methods From March 2006 to May 2011,52 paraffin samples of human hepatocellular carcinoma tissues were obtained,and the expression of PEG10 was examined by immunohistochemical staining.Another 31 normal tissues adjacent to human hepatocellular carcinoma and 10 normal liver tissues and 10 normal placenta tissues were served as controls.The clinicopathological data of 52 patients with hepatocellular carcinoma were retrospectively analyzed,and their relationship with the expression of PEG10 was analyzed.Results The positive expression rate of PEG10 in human hepatocellular carcinoma tissues was 90.38%(47/52),which was significantly higher than that in normal tissues adjacent to human hepatocellular carcinoma(67.74%,21/31) and normal liver tissues(0)(P0.01).The expression of PEG10 was positively correlated with the different differentiation of hepatocellular carcinoma(r=0.441,P0.01).There was no significant difference in the expression of PEG10 among patients with the different differentiation of tumor size age and gender(P0.05).Conclusion The expression of PEG10 is correlated with the pathology stage.The sensitivity of hepatocellular carcinoma is good,but its specificity is not strong.