The Significance of P27 Expression in Hepatocellular Carcinoma

Objective To investigate the expression of P27 protein in hepatocellular carcinoma and its relationship with clinic pathology.Methods P27 protein was measured by immunohistochemistry methos(S-P method)and the posotive cells of P27 were analyzed by computer image analsis system.Results The mean optical density of P27 is significantly connected with ther malignant grade of hepatocellular carcinoma.the mean optical density of P27 in the hepaticellular carcinoma which well differentiated,had no cancerous and was less than 3cm in diameter was significantly highly than in the hepatocellular carcinoma which differentiated worse,had canceious embolus and was above 3cm in diameter.Conclusion The decreased expression of P27 is strikingly related to malignacy and biological aggressiveness in hepatocellular carcinoma,thich may serve as one of a new prognosis factor in hepatocellular carcinoma.