Produing extended-spectrum β-lactamases strains:detection infection and resistance

Objective:To investigate the kinds,distribution and antibiotic resistance of producing extended-spectrum β-lactamases(ESBLs)bacteria in hospital.Methods:The producing ESBLs bacteria were betected by double-disk synergy test with indicators of Aztreonam,Cefotaxime,Ceftriaxone and Ceftazidime.Results:Among 716 gram-negative bacterial isolates producing 114 ESBLs bacteria in 12 kinds were detected.most producing ESBLs bacteria came from the patients treated with the third generation cephalosporins The bcacteria detected were mainly Enterobacter cloacae(Ecl),Klebsiella pneumoniae(Kpn)and Escherichia coli (Ecoli). Their prevalence of ESBLs in isolates of E.Colacae.K.pn and E.coli,were 34.66%(26/75),19.37%(25/129)and 14.75%(36/244)respectively. The best indicators were Aztreonarn and Cefotaxime.The resistance for cephalosporins and Aztreonarn in producing ESBLs strains was signifycant higher than that of no producing ESBLs.Besides Xanthomonas maltophilia,all producing ESBLs strains were susceptible to Imopenem.Conclusion:Producing ESBLs strains were mainly E.cloacae,K.pneumoniae and E.coli.Their production was related with using the third generation cephalosporins.The resistant plasmid can transmit between bacteria each other.The antibiotic susceptible to producing ESBLs strains could be chosen in treating ESBLs infection.