Clinical effective analysis of high frequency oscillatory ventilation in treatment of neonatal respiratory distress syndrome

Objective:To evaluate the efficacy and safety of high frequency oscillatory ventilation (HFOV) in treatment of neonatal respiratory distress syndrome(NRDS) and neonatal acute respiratory distress syndrome(ARDS).Methods:Eight hundred and forty eight cases infants with NRDS and 248 cases with ARDS from Jan.1997～ Jun.2007 were enrolled in the comparing study.The infants treated by HFOV were regarded as case group (516 cases with NRDS,156 cases with NRDS),the cases inhaled oxygen with nasal catheter,face mask,or CPAP were regarded as control group (332 cases with NRDS,92 cases with ARDS).Their difference according to blood-gas analysis,days in hospital,successful rate and complications were compared.Results:After 24 and 72 hours of treatment,PaO\-2,pH were significant improved and PaCO\-2,OI were greater descended in case group.Successful rate was higher in case group.Days in hospital and complications of case group were lower than control group (P0.05).Conclusion:HFOV is efficient and safe for the treatment of NRDS and ARDS.It can rapidly improve oxygenation,decrease complication and hospitalization time.HFOV is a new kind of safe and effective ventilation mode.