Clinical Observation of Shenmai Injection in the Treatment and Prevention of Neurotoxicity Induced by Chemotherapy Regimen Containing Taxtol

OBJECTIVE:To observe the curative effect of Shenmai injection on the treatment and prevention of the neurotoxicity caused by chemotherapy regimen including taxtol.METHODS:125 cancer patients who received chemotherapy regimen including taxtol were randomly divided into trial group(64 patients)and control group(61 cases).Trial group began to use Shenmai injection 50 mL added into 5% Glucose injection 200 mL 1 day before chemotherapy,14 d as a treatment period,i.v.gtt.The therapeutic efficacy was evaluated,variation of neurotoxicity was observed and peripheral nerve function was detected after 4 cycles.RESULTS:The incidence of neurotoxicity in the trial group was 26.6%(17/64)and 57.4% in control group(35/61),there was statistical significance in the difference between 2 groups(P0.05).Determination of peripheral nerve function,the nervus peronaeus motor nerves conduction velocity(MNCV) of trial group and control group was(41.9±2.2) m·s-1 and(36.3±3.2) m·s-1,respectively;the sensory nerves conduction velocity(SNCV) was(42.5±4.2) m·s-1 and(35.5±3.3) m·s-1;the eclipse period of motion nerves teleneuron was(4.1±1.5) ms and(4.7±1.1) ms;the action potential amplitude of sensory nerves was(9.1±4.2) μV and(7.3±3.3) μV.There was statistical significance between 2 groups(P0.05).CONCLUSIONS:Shenmai injection is effective in the prevention and treatment of the neurotoxicity caused by chemotherapy regimen including taxtol.