The effect of valsartan and amlodipine tablets on the improvement of arterial elasticity and carotid intima-media thickness in patients with hypertension

Objective: To investigate the effects of valsartan and amlodipine tablets on the improvement of arterial elasticity and carotid intima-media thickness( C-IMT) in patients with hypertension. Methods: Eighty patients with hypertension were divided into the treatment group and control group( 40 cases each group). The treatment group and control group were treated with 80 mg / d of valsatan combined with 5 mg / d of amlodipine and 12. 5 mg / d of hydrochlorothiazide combined with 5 mg / d of amlodipine by daily oral for 1 year,respectively. The carotid-femoral pulse wave velocity( CF-PWV),large and small arterial elastic indexes( C1 and C2), augumentation index and C-IMT in two groups were measured before and after treantment. Results: Compared with the control group after treatment,the CF-PWV was slow down,the indexes of C1 and C2 and pressurised reflected wave were increased,and the C-IMT were decreased in treatment group( P 0. 01). The brachial artery blood pressure in 2 groups were decreased significantly after treatment( P 0. 01). The difference of which was not satistically significant( P 0. 05). Conclusions: The valsartan combined with amlodipine can significantly reduce the hypertension and C-IMT,and improve the arterial elasticity in patients with hypertension.