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2002•Chinese Journal of PharmaceuticalsRequires access

Preparation and Physicochemical Properties of Carbamazepine Loaded Stearic Acid Solid Lipid Nanoparticles

Ying Xiao

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Abstract

Carbamazepine loaded stearic acid solid lipid nanoparicles(SLN) were prepared, and its particle size, morphology, zeta potential, entrapment efficiency and drug release in vitro were studied. The stearic acid SLN was prepared by the procedure of emulsification and solvent evaporation. The characteristic data showed that the volume mean diameter ( D 50 ) of the SLN was 120±9.8 nm,zeta potential was -50.6±3.3 mV,average entrapment efficiency was 89.8% and drug release profiles in vitro were in accordance with Higuchi equation and exhibited obvious sustained release effects.

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Carbamazepine loaded stearic acid solid lipid nanoparicles(SLN) were prepared, and its particle size, morphology, zeta potential, entrapment efficiency and drug release in vitro were studied. The stearic acid SLN was prepared by the procedure of emulsification and solvent evaporation. The characteristic data showed that the volume mean diameter ( D 50 ) of the SLN was 120±9.8 nm,zeta potential was -50.6±3.3 mV,average entrapment efficiency was 89.8% and drug release profiles in vitro were in accordance with Higuchi equation and exhibited obvious sustained release effects.

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Available abstract

Carbamazepine loaded stearic acid solid lipid nanoparicles(SLN) were prepared, and its particle size, morphology, zeta potential, entrapment efficiency and drug release in vitro were studied. The stearic acid SLN was prepared by the procedure of emulsification and solvent evaporation. The characteristic data showed that the volume mean diameter ( D 50 ) of the SLN was 120±9.8 nm,zeta potential was -50.6±3.3 mV,average entrapment efficiency was 89.8% and drug release profiles in vitro were in accordance with Higuchi equation and exhibited obvious sustained release effects.

Key concepts: Stearic acid, Chemistry, Solid lipid nanoparticle, Zeta potential, Particle size, Carbamazepine, Chromatography, Solvent

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