Preparation,Characterization and Drug Release of Biodegradable Solid Lipid Nanoparticles

Biodegradable solid lipid nanoparticles loaded with pueraria flavones(PF-SLN) were prepared by emulsification evaporation-solidification at low temperature with a biodegradable material,stearic acid as the carrier.The morphology and particle size of PF-SLN were measured by TEM and laser light scattering technique,respectively.The physical status of the drug in PF-SLN was analyzed by X-ray powder diffractometry.Its entrapment efficacy in SLN and release were also investigated.PF-SLN is near spherical in shape and the average diameter is(263.82 ± 3.6) nm.Its entrapment effciency(EE) is(67.53 ± 0.12) %.X-ray powder diffraction analysis results show that the pueraria flavones are dispersed with the state of molecular or tiny particles in the matrix of SLN.The results show that the release of PF-SLN occurs rapidly in the early stage and then slowly which accumulate up to 50% in 12 h.The drug release slowly from SLN following matrix erosion.The release profile fits well to the Higuchi equation.