Spectrum of pediatric non-viral liver disease during 2001-2010

Objective To investigate the proportion of pediatric non-viral liver disease to pediatric liver disease,liver dis-ease spectrum and its proportion so as to provide evidence for the prevention and treatment of pediatric non-viral liver disease.Methods Clinical data of 703 pediatric patients with non-viral liver disease,who were admitted to our hospital from Jan.2001 to Dec.2010 and received liver biopsy,were analyzed retrospectively,and compared with that of the pediatric patients with non-viral liver disease admitted from Jun.1983 to Dec.2000.Results The proportion of pediatric non-viral liver disease to pediatric liver dis-ease was 17.53% from Jan.2001 to Dec.2010,with an increasing tendency,especially during the past two years (an increase of over 20%).The difference was significant between the proportion from Jan.2001 to Dec.2010 and that from Jun.1983 and Dec.2000 (χ2=38.129,P=0.000).The spectrum of pediatric non-viral liver disease covered 66 kinds of liver diseases in the enrolled individu-als from Jan.2001 to Dec.2010.Among them,hepatic metabolism-related disease accounted for the largest proportion (46.23%),among which hepatolenticular degeneration accounted for 48.92% of the single disease.Biliary-related disease accounted for 11.66%,drug-induced hepatitis 10.53% and non-alcoholic fatty liver disease 7.45%.It could not be ignored that the incidence of non-viral liver disease combined with viral hepatitis was 11.2%.The final diagnosis of 4.8% intractable cases of pediatric non-viral liver dis-ease was confirmed by some special methods such as genetic technology,etc.Conclusions The number of the patients with pedi-atric non-viral liver disease has surprisingly increased in China over the past 10 years.The liver disease spectrum has expanded quickly and the proportion has changed significantly compared with the past.It can not be ignored that the number of pediatric pa-tients with non-viral liver disease combined with viral hepatitis is not small.Furthermore,the development of diagnostic technique contributes to the confirmed diagnosis of intractable cases of pediatric non-viral liver disease.