A Clinical Retrospective Study of 179 Cases of Drug-induced Liver Disease

Objective To analyze drug-induced liver disease case so as to explore its common pathogeny,occurrence regularity,clinical characteristics and therapeutic outcomes.Methods 179 cases of inpatients with drug-induced liver disease were investigated to analyze the correlated factors.Results The species caused drug-induced liver disease were various. Traditional Chinese Medicine stood out as the first drug related to drug-induced liver disease(44.2%). The second cause was antibiotics(24.6%),including antituberculous drugs(13.4%).Most cases’incubation period was 1～8 weeks(64.8%),while for a few cases(26.8%),the incubation period of liver function injury after using drugs exceeded 12 weeks.The cholestasis pattern of damage was the most common(57.5%).Gravis type of hepatitis was few.The main clinical manifestations included debility(54.8%),decreased appetite(61.5%),jaundice(65.4%).Conclusions The commonest cause of drug-induced liver disease is Traditional Chinese Medicine.Its main clinical type is the cholestasis one.Detailed asking medication usage and monitoring liver function before and after the period of taking drugs are the two key factors of diagnosing drug-induced liver disease.We should actively set up databases about drug-induced liver disease.