Pharmacokinetics of self-microemulsifying drug delivery system of simvastatin in Beagle dogs

AIM To evaluate the pharmacokinetics of self-microemulsifying drug delivery system of simvastatin(SV-SMEDDS) in Beagle dogs.METHODS Plasma simvastatin was determined by RP-HPLC with solid-phase extraction using Waters OASIS○ R HLB cartridge.The pharmacokinetics of SV-SMEDDS was evaluated after a single oral dose of 40 mg of simvastain in a two-period crossover experiment design compared with simvastatin suspension(SV-Sus).RESULTS The pharmacokinetics of both SV-SMEDDS and SV-Sus fitted to two-compartment model.The tmax were(0.84±0.26) and(0.99±0.32)h for SV-SMEDDS and SV-Sus respectively,and ρmax were(39.73 ± 9.11) and(28.54±7.76)μg·L-1 respectively.SV-SMEDDS showed a relative bioavailability of 184.84%.CONCLUSION SMEDDS is able to increase the absorbance and bioavailability of simvastatin.