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2010•Chinese Journal of Hospital PharmacyRequires access

Pharmacokinetic study of oleanolic acid self-microemulsifying system in rat

Yang Rui

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Abstract

OBJECTIVE To study the pharmacokinetic behavior of oleanolic acid self-microemulsifying drug delivery system(OA-SMEDDS)in rats.METHODS Concentrations of OA in rat plasma were determined by HPLC-MS.The plasma concentration-time profile of OA-SMEDDS was obtained and pharamcokinetic parameters were calculated using DAS ver 2.0with conventional tablet as reference.RESULTS The plasma concentration data of OA-SMEDDS and conventional tablet were both fitted to two-compartment model.The tmaxof OA-SMEDDS was decreased,while Cmaxand AUC were significantly increased,compared with reference tablet.CONCLUSION The self-microemulsifying drug delivery system significantly enhanced the absorption of OAin vivo and thus improved its bioavailability.

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What this paper is about

OBJECTIVE To study the pharmacokinetic behavior of oleanolic acid self-microemulsifying drug delivery system(OA-SMEDDS)in rats.METHODS Concentrations of OA in rat plasma were determined by HPLC-MS.The plasma concentration-time profile of OA-SMEDDS was obtained and pharamcokinetic parameters were calculated using DAS ver 2.0with conventional tablet as reference.RESULTS The plasma concentration data of OA-SMEDDS and conventional tablet were both fitted to two-compartment model.The tmaxof OA-SMEDDS was decreased,while Cmaxand AUC were significantly increased,compared with reference tablet.CONCLUSION The self-microemulsifying drug delivery system significantly enhanced the absorption of OAin vivo and thus improved its bioavailability.

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Available abstract

OBJECTIVE To study the pharmacokinetic behavior of oleanolic acid self-microemulsifying drug delivery system(OA-SMEDDS)in rats.METHODS Concentrations of OA in rat plasma were determined by HPLC-MS.The plasma concentration-time profile of OA-SMEDDS was obtained and pharamcokinetic parameters were calculated using DAS ver 2.0with conventional tablet as reference.RESULTS The plasma concentration data of OA-SMEDDS and conventional tablet were both fitted to two-compartment model.The tmaxof OA-SMEDDS was decreased,while Cmaxand AUC were significantly increased,compared with reference tablet.CONCLUSION The self-microemulsifying drug delivery system significantly enhanced the absorption of OAin vivo and thus improved its bioavailability.

Key concepts: Bioavailability, Pharmacokinetics, Oleanolic acid, Chemistry, Pharmacology, Drug delivery, Absorption (acoustics), Plasma concentration

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