2006•Xiandai shengwu yixue jinzhanRequires access
Assessment of simvastatin with a self-emulsifying capsule in vivo
Tian Da-feng
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Abstract
Objective: To evluate the self-microemulsifying ablity and dissolution behavior of simvastatin in vitro and the pharmacokinetic behavior in beagle dogs.Methods: The plasma concentrations were evaluated by HPLC and dissolution and pharmacokinetic behavior of self-microemulsifying formulations were evaluated by comparison with commercial tablets.Results: The area under the curve(AUC) was significantly higher in the simvastatin self-microemulsifying capsules group than that in the commercial tablets group.Also,T_(max) was smaller and C_(max) was much higher in the simvastatin self-microemulsifying capsules group compared with market products.Conclusion: The self-microemulsifying capsule can increase absorption in vivo significantly.