The study on changes of serum hepatic function and renal function in patients with acute organophosphorus pesticide poisoning

Objective To explore the changes of hepatic function and renal function in patients with organophosphorus pesticide poisoning.Methods Blood simples were taken for measurement of serum hepatic function,renal function and cholinesterase(ChE) of 61 cases with acute organophosphorus pesticide poisoning were examinated within 20 hours after intoxication.Moreover,to compare the change of hepatic function and renal function between recovery group(n=61) and control group(n=65)individually.Results In mild poisoning cases,ChE decreased obviously(P0.001);in moderate poisoning cases,Serum total bilirubin(TBIL),direct bilirubin(DBIL),blood urea nitrogen(BUN) and aspartate aminotransferase(AST) levels were increased obviously,but total protein(TP),uric acid(UA) and ChE levels were decreased obviously(all P0.001);in severe poisoning cases,TBIL,DBIL,glutamicpyruvic transaminase(ALT),AST,creatinine(Cr) and BUN levels were raised obviously,TP,UA,Albumin(ALB),ChE were decreased obviously(all P0.001).7 of 13 cases with cardiac arrest or respiratory muscular paralysis in poisoning group had most remarkable changes of these serum indices and died.Conclusion To observe changes of serum hepatic function and renal function in patients with acute organophosphorus poisoning have a great value in judging the degree of poisoning or prognosis.