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Changes of hepatic function and enzymogram in patients with acute organophosphorus pesticide poisoning.

Jiashun Wang

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Abstract

Objective:To study the changes of hepatic function and enzymogram in patients with acute organophosphorus pesticide poisoning.Methods:Blood samples were taken for the determination of serum hepatic function,enzymogram in 46 patients with acute organophosphorus pesticide poisoning within 20 h after intoxication and at the end of treatment.The results were compared with the control group(n=40).Results:Compared with the control group,in the poisoning cases,the total protein and the albumin(P0.05)decreased strikingly.For the mild and moderate cases,there were no significant difference in the total bilirubin(TBIL),direct bilirubin(DBIL),aspartate aminotransferase(AST),γ-glutamyl transferase(GGT)and alkaline phosphatase(ALP).In some severe cases,the alanine transaminase(ALT),AST levels elevated slightly(P0.05).For severe cases,there was no significant difference in TBIL,DBIL,GGTand ALP.Conclusion:There are changes of hepatic function impairment in some severe patients with acute organophosphorus pesticide poisoning,the changes are reversible.

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Objective:To study the changes of hepatic function and enzymogram in patients with acute organophosphorus pesticide poisoning.Methods:Blood samples were taken for the determination of serum hepatic function,enzymogram in 46 patients with acute organophosphorus pesticide poisoning within 20 h after intoxication and at the end of treatment.The results were compared with the control group(n=40).Results:Compared with the control group,in the poisoning cases,the total protein and the albumin(P0.05)decreased strikingly.For the mild and moderate cases,there were no significant difference in the total bilirubin(TBIL),direct bilirubin(DBIL),aspartate aminotransferase(AST),γ-glutamyl transferase(GGT)and alkaline phosphatase(ALP).In some severe cases,the alanine transaminase(ALT),AST levels elevated slightly(P0.05).For severe cases,there was no significant difference in TBIL,DBIL,GGTand ALP.Conclusion:There are changes of hepatic function impairment in some severe patients with acute organophosphorus pesticide poisoning,the changes are reversible.

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Available abstract

Objective:To study the changes of hepatic function and enzymogram in patients with acute organophosphorus pesticide poisoning.Methods:Blood samples were taken for the determination of serum hepatic function,enzymogram in 46 patients with acute organophosphorus pesticide poisoning within 20 h after intoxication and at the end of treatment.The results were compared with the control group(n=40).Results:Compared with the control group,in the poisoning cases,the total protein and the albumin(P0.05)decreased strikingly.For the mild and moderate cases,there were no significant difference in the total bilirubin(TBIL),direct bilirubin(DBIL),aspartate aminotransferase(AST),γ-glutamyl transferase(GGT)and alkaline phosphatase(ALP).In some severe cases,the alanine transaminase(ALT),AST levels elevated slightly(P0.05).For severe cases,there was no significant difference in TBIL,DBIL,GGTand ALP.Conclusion:There are changes of hepatic function impairment in some severe patients with acute organophosphorus pesticide poisoning,the changes are reversible.

Key concepts: Medicine, Bilirubin, Alkaline phosphatase, Alanine transaminase, Internal medicine, Liver function, Aspartate transaminase, Albumin

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Changes of hepatic function and enzymogram in patients with acute organophosphorus pesticide poisoning. — Research Paper | ScholarLens