Changes of serum cholinesterase and creatine phosphokinase in patients with acute organophosphorus pesticides poisoning.

Objective To study the changes and clinical significances of serum cholinesterase(ChE) and creatine phosphokinase(CPK) in patients with acute organophosphorus pesticides poisoning(AOPP).Methods According to the poisoning degree,90 patients were divided into mild degree poisoning group(n=30),moderate degree poisoning group(n=30),and severe degree poisoning group(n=30),30 healthy persons were selected as control group.Cardiac functions of the patients were monitored.Results In comparison with healthy control group,the levels of CPK in patients with AOPP were increased to various degree(P0.01) and the increased degrees were parallel to poisoning degrees.The activities of ChE were decreased to various degree,but the decreased degrees were not parallel to poisoning degree.Conclusion The more significantly serum CPK levels increase,the more severe the poisoning degrees of the patients are,therefore the worse the prognosis of the patients is.It has important significance for diagnosis confirmation and severity judgement.The decrease in ChE activities has important significance only for diagnosis confirmation;when you are giving a judgement on the severity,it is for reference only.