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2010•Medical Journal of CommunicationsRequires access

The correlation between the expression of EGFR and lymph node metastasis in Esophageal Squamous Cell Carcinoma

Hongbin Liu

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Abstract

Objective:To investigate the correlation between the expression of EGFR and lymph node metastasis in Esophageal Squamous Cell Carcinoma(ESCC).Methods:The expression of EGFR in 80 ESCC was measured by immunohistochemistry,and to the relationship between the expression of EGFR and lymph node metastasis in ESCC was analyzed.All data were analyzed by chi-square test,Pearson rank correlation analysis.Results:The positive rate of EGFR in 80 ESCC and 20 normal esophageal tissues were 61.3% and 20.0% respectively.The positive rate of EGFR in ESCC was much higher than in normal esophageal tissues(χ2=10.63,P0.05).The positive rate of EGFR was positively correlated with lymph node metastasis(P 0.05).Conclusions:EGFR was more highly expressed in ESCC than in normal esophageal tissues and was positively correlated with lymph node metastasis.

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Objective:To investigate the correlation between the expression of EGFR and lymph node metastasis in Esophageal Squamous Cell Carcinoma(ESCC).Methods:The expression of EGFR in 80 ESCC was measured by immunohistochemistry,and to the relationship between the expression of EGFR and lymph node metastasis in ESCC was analyzed.All data were analyzed by chi-square test,Pearson rank correlation analysis.Results:The positive rate of EGFR in 80 ESCC and 20 normal esophageal tissues were 61.3% and 20.0% respectively.The positive rate of EGFR in ESCC was much higher than in normal esophageal tissues(χ2=10.63,P0.05).The positive rate of EGFR was positively correlated with lymph node metastasis(P 0.05).Conclusions:EGFR was more highly expressed in ESCC than in normal esophageal tissues and was positively correlated with lymph node metastasis.

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Available abstract

Objective:To investigate the correlation between the expression of EGFR and lymph node metastasis in Esophageal Squamous Cell Carcinoma(ESCC).Methods:The expression of EGFR in 80 ESCC was measured by immunohistochemistry,and to the relationship between the expression of EGFR and lymph node metastasis in ESCC was analyzed.All data were analyzed by chi-square test,Pearson rank correlation analysis.Results:The positive rate of EGFR in 80 ESCC and 20 normal esophageal tissues were 61.3% and 20.0% respectively.The positive rate of EGFR in ESCC was much higher than in normal esophageal tissues(χ2=10.63,P0.05).The positive rate of EGFR was positively correlated with lymph node metastasis(P 0.05).Conclusions:EGFR was more highly expressed in ESCC than in normal esophageal tissues and was positively correlated with lymph node metastasis.

Key concepts: Immunohistochemistry, Lymph node metastasis, Medicine, Esophageal squamous cell carcinoma, Esophageal Neoplasm, Oncology, Metastasis, Esophageal cancer

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