ScholarLens Back to search
2005•Unpublished venueRequires access

THE RELATIONSHIP BETWEEN THE CHANGES OF IMMUN FUNCTIONAND THE BACTERIAL DISPLACEMENT IN EXPERIMENTAL ACUTE PANCREATITIS IN RATS

Zeyan Duan

Open publisher page 0 citations

Abstract

Objective: To investigate the relationship between the changes of immune function and the bacterial translocation in experimental severe acute pancreatitis(SAP) in rats. Methods: Twenty Wistar rats were randomly divided into two groups: models group of SAP(M,n=10);control group(C,n=10). SAP group were induced by injecting adversely 5 % sodium taurocholate into the common biliary-pancreatic duct. The per-centages of CD4+ and CD8+ lymphocyte were determined by theflow cytometry. Bacterial culture in pancreas,blood and mensentericlymph nodes(MLN) were made. Results: Thepercentages of CD4+ and CD4+/CD8+ratio in SAP group were significantly lower than those in control group(P0.01). However the positive ratesofcultured bacteria were significantly higher than that of control group (P0.01). Conclusion: ①There exists damage of cellular immunity function in pancreatitis;②There is relationship betweenintestinal bacterial translocation and damage of cellular immune function.

About this research paper

What this paper is about

Objective: To investigate the relationship between the changes of immune function and the bacterial translocation in experimental severe acute pancreatitis(SAP) in rats. Methods: Twenty Wistar rats were randomly divided into two groups: models group of SAP(M,n=10);control group(C,n=10). SAP group were induced by injecting adversely 5 % sodium taurocholate into the common biliary-pancreatic duct. The per-centages of CD4+ and CD8+ lymphocyte were determined by theflow cytometry. Bacterial culture in pancreas,blood and mensentericlymph nodes(MLN) were made. Results: Thepercentages of CD4+ and CD4+/CD8+ratio in SAP group were significantly lower than those in control group(P0.01). However the positive ratesofcultured bacteria were significantly higher than that of control group (P0.01). Conclusion: ①There exists damage of cellular immunity function in pancreatitis;②There is relationship betweenintestinal bacterial translocation and damage of cellular immune function.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective: To investigate the relationship between the changes of immune function and the bacterial translocation in experimental severe acute pancreatitis(SAP) in rats. Methods: Twenty Wistar rats were randomly divided into two groups: models group of SAP(M,n=10);control group(C,n=10). SAP group were induced by injecting adversely 5 % sodium taurocholate into the common biliary-pancreatic duct. The per-centages of CD4+ and CD8+ lymphocyte were determined by theflow cytometry. Bacterial culture in pancreas,blood and mensentericlymph nodes(MLN) were made. Results: Thepercentages of CD4+ and CD4+/CD8+ratio in SAP group were significantly lower than those in control group(P0.01). However the positive ratesofcultured bacteria were significantly higher than that of control group (P0.01). Conclusion: ①There exists damage of cellular immunity function in pancreatitis;②There is relationship betweenintestinal bacterial translocation and damage of cellular immune function.

Key concepts: Medicine, Acute pancreatitis, Immune system, Pancreatitis, CD8, Internal medicine, Cellular immunity, Immunologic function

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
THE RELATIONSHIP BETWEEN THE CHANGES OF IMMUN FUNCTIONAND THE BACTERIAL DISPLACEMENT IN EXPERIMENTAL ACUTE PANCREATITIS IN RATS — Research Paper | ScholarLens