2007•Shandong yiyaoRequires access

Change of TGF-β_1 in patients with diabetic nephropathy and it's intervention with valsartan

Yanhua Li

Abstract

[Objective] To study the change of transforming growth factor-β_1(TGF-β_1) in patients with diabetic nephropathy and it's intervention with valsartan.[Methods] 62 type 2 diabetes patients were divided into two groups according to the level of urinary albumin excretion rate(UAER).The levels of TGF-β_1,blood sugar and urinary renal function were measured in all patients and normal controls.Above markers were measured after valsartan was given.[Results] The levels of UAER and TGF-β_1 in patients with diabetic nephropathy were significantly higher than that in normal controls(P0.01).The level of UAER positively correlated with the level of TGF-β_1 in patients with diabetic nephropathy.After 8 weeks of valsartan therapy,the levels of UAER and TGF-β_1 decreased significantly in patients with diabetic nephropathy.[Conclusion] There is a positive correlation between TGF-β_1 and UAER in patients with diabetic nephropathy.Valsartan can decrease the level of TGF-β_1 and improve the renal function of patients with diabetic nephropathy.

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Key concepts: Diabetic nephropathy, Medicine, Valsartan, Internal medicine, Excretion, Renal function, Endocrinology, Urology