The expression and clinical significance of Smad4 and p53 in non-small cell lung carcinoma

Purpose To investigate the expression of Smad4 and p53 protein,and observed their significance on clinical pathological characteristic in non-small cell lung carcinoma(NSCLC).Methods The expression of Smad4 and p53 protein was detected in 150 cases of NSCLC,60 cases of normal lung tissues by immunohistochemistry.Results The lower expression of Smad4,higher expression of p53 was observed in NSCLC(P0.05).Smad4 and p53 protein expression was related to NSCLC differentiation,lymph node metastasis,pleural invasion and clinical stage(P0.05).The expression of Smad4 and p53 was correlated with prognosis in NSCLC(P0.05).Conclusion The abnormal expression of Smad4 and p53 protein may be correlated with malignant biological behavior in NSCLC.The combined detection of Smad4 and p53 may helpful to predict the prognosis in NSCLC.