The expression of p73,p63 and p53 gene in non-small cell lung carcinoma and their relations with the prognosis

Objective:To explore the expression and relations with prognosis of p53,p63 and p73 in non-small cell lung cancer(NSCLC).Methods:The expression of p53、p63 and p73 in 93 cases of NSCLC were checked by Immunohistochemistry.The relations with the expression of p53,p63 and p73 and the multiple factors of age,gender,smoking,pathological type,differentiation,stage,lymph node metastasis and survival time were analyzed statistically.Results: The expression rates of p53、p63 and p73 in normal lung tissue sections were 25、25 and 12.5,respectively.and the expression rates of p53、p63 and p73 in the 93 NSCLC were 65.6,54.8 and 71,respectively(P0.05).The expression of p53 was associated with lympha node metastasis(P0.05).The expression of p63 was associated with lympha node metastasis and pathological type(P0.05).The expression rates of p63 in squamous cells lung cancer were highly expressed along with lower histological differentiation.Conclusions:p53,p63 and p73 contribute to the development,invasion and metastasis of NSCLC,which suggested to know the biological behavior and judge the prognosis of NSCLC.