The chromosome analysis of 317 cases genetic counselors in Dongguan

Objective: To investigate the relationship between chromosome abnormalities and different types of diseases(Mental retardation,Infertility,Primary amenorrhea or Azoospermia).Methods: 317 cases of patients collected from genetic counselor of Dongguan Kanghua Hospital were detected by lymphocyte chromosome G-banding method in peripheral blood.Results:The results show that 62 out of 317 cases had karyotype aberration(19.55%),Among 25 cases(40.32%) are autosomal abnormalities,13 cases(20.97%) are sex chromosomal abnormality,24 cases(38.71%) are chromosomal polymorphism.Conclution:Chromosome abnormalities are the important factors leading to mental retardation,abnormal gestation and birth,sexual development abnormity and idopathic azoospermiam.