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Spectrophotometric Determination of Bisoprofolfumarat Based on a Charge Transfer Reaction

Cai Don

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Abstract

Based on the charge transfer reaction between drug and chromogenic reagent,a simple and rapid method for the determination of bisoprofolfumarat was developed.Bisoprofolfumarat can react with alizarin red to form 1∶1complex after being placed for 15minutes in room temperature,which gives a maximum absorption peak at 535nm.The molar absorptivity of the complex was 6.76×103/(mol·cm)the linear range was 10~100mg/L,and the linear equation was A =0.085+0.00712c,with r=0.99904.the RSD was 0.44%(n=6).When it was applied for the determination of bisoprofolfumarat tablets,the recoveries were between 98.3%~102.6%.

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What this paper is about

Based on the charge transfer reaction between drug and chromogenic reagent,a simple and rapid method for the determination of bisoprofolfumarat was developed.Bisoprofolfumarat can react with alizarin red to form 1∶1complex after being placed for 15minutes in room temperature,which gives a maximum absorption peak at 535nm.The molar absorptivity of the complex was 6.76×103/(mol·cm)the linear range was 10~100mg/L,and the linear equation was A =0.085+0.00712c,with r=0.99904.the RSD was 0.44%(n=6).When it was applied for the determination of bisoprofolfumarat tablets,the recoveries were between 98.3%~102.6%.

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Available abstract

Based on the charge transfer reaction between drug and chromogenic reagent,a simple and rapid method for the determination of bisoprofolfumarat was developed.Bisoprofolfumarat can react with alizarin red to form 1∶1complex after being placed for 15minutes in room temperature,which gives a maximum absorption peak at 535nm.The molar absorptivity of the complex was 6.76×103/(mol·cm)the linear range was 10~100mg/L,and the linear equation was A =0.085+0.00712c,with r=0.99904.the RSD was 0.44%(n=6).When it was applied for the determination of bisoprofolfumarat tablets,the recoveries were between 98.3%~102.6%.

Key concepts: Chemistry, Chromogenic, Molar absorptivity, Reagent, Linear range, ALIZARIN RED, Chromatography, Linear relationship

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