Study of Quadruple Therapy on Peptic Ulcer

Objective:To analyze the clinical outcomes and recurrence after treatment of quadruple therapy for peptic ulcer infected Helicobacter pylori. Method:120 patients with peptic ulcer infection with Hp of our hospital were randomly divided into observation group and control group.There were 60 cases of each group.The control group were treated with omeprazole,amoxicillin and clarithromycin treatment.The observation group were treated with quadruple therapy treatment including omeprazole,amoxicillin,clarithromycin and bismuth potassium citrate.To compare the peptic ulcer healing and Hp eradication and relapse rate situation of two groups after treatment. Result: The total effective rate of observation group was 93.33%, which was significantly higher than 90.00% of control group.But there was no statistically significant difference (P0.05).The Hp eradication rate of observation group was 93.34%, which was significantly higher than 75.00% of control group.The recurrence rate of patients in observation group and control group were 3.33% and 11.67%.The differences of Hp eradication rate and recurrence rate between two groups were statistically significant (P0.05). Conclusion:The clinical efficacy of quadruple therapy for peptic ulcer was significant.Quadruple therapy has the effective rate, Hp eradication rate, and fewer adverse reactions, which is one of the safe and effective method of treatment foe peptic ulcer. It is worth the promotion of clinical application.