Clinical effect and safety of quadruple therapy in the treatment of Helicobacter pylori related peptic ulcer

Objective To observe the clinical effects and safety of using quadruple therapy to treat Helicobacter pylori( H. pylori) related peptic ulcer. Methods 160 patients with H. pylori related peptic ulcer admitted from May 2013 to June 2014 in our hospital were selected and randomly divided into the observation group and the control group( 80 cases in each group). The observation group was treated with quadruple therapy using lansoprazole,amoxicillin,clarithromycin and colloidal bismuth pectin,while the control group was given triple therapy including lansoprazole,amoxicillin and clarithromycin. The clinical remission rate,ulcer healing rate,H. pylori eradication rate and adverse reactions of the two groups were recorded and compared. Results The clinical remission rates of the two groups at 1 week after treatment was not statistically different( χ2= 2. 064,P 2. 064); the clinical remission rate of the observation group was 96. 25% at 4 weeks after treatment,significantly higher than that of the control group which was 81. 25%( χ2= 9. 014,P 0. 05). The ulcer healing rate in observation group was 88. 75%,significantly higher than that in control group which was 77. 5%( χ2= 4. 449,P 0. 05). H. pylori eradicate rate in the observation group was 91. 25%,significantly higher than the 76. 25% in control group( χ2= 6. 613,P 0. 05). There were no liver or kidney dysfunction and other serious adverse reactions,and the incidence of adverse reactions in the two groups had no statistical significance( χ2= 0. 278,P 0. 278). Conclusion Standard quadruple therapy has higher clinical remission rate and H. pylori eradicate rate in the treatment of H. pylori related peptic ulcer with higher ulcer healing rate and safety,which is worthy of clinical promotion.