2005•PubMedRequires access

[Detection of glucocorticoid receptor-alpha mRNA expression using FQ-RT-PCR in nasal polyp].

Peng Li, Yuan Li, Xiaowen Zhang, Gehua Zhang, Ye Jin, Yanan Sun, Bin Hu

Abstract

OBJECTIVE: To detect the expression of the glucocorticoid receptor-alpha (GR-alpha) mRNA in nasal polyp and normal nasal mucosa and investigate the significance of GR-alpha in progression of nasal polyp. METHOD: The expression of GR-alpha mRNA in 36 samples of nasal polyp and 31 samples of normal nasal mucosa was examined by using fluorescent quantitative PCR(FQ RT-PCR). RESULT: The GR-alpha mRNA levels in normal nasal mucosa [(135.4 +/- 5.2) x 10(10) copy/g] were significantly higher than those in nasal polyp [(25.5 +/- 5.0) x 10(10) copy/g] (P < 0.01). CONCLUSION: The low expression of GR-alpha mRNA in nasal polyp is related to the progression of nasal polyp.

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Key concepts: Glucocorticoid receptor, Mucous membrane of nose, Nasal polyps, Messenger RNA, Real-time polymerase chain reaction, Alpha (finance), Glucocorticoid, Receptor