Influence of ovarian high response on pregnancy outcome of in vitro fertilization and embryo transfer

Objective To investigate the influence of high ovarian response on quality of oocyte and embryo,pregnancy outcome in IVF /ICSI cycles. Methods A retrospective study was designed covering 259 infertile patients with male and / or tubal factor who were admitted to first IVF / ICSI treatment from January 2012 to December 2012.All cases were divided into high responder group( n = 114) and normal responder group( n = 145) according to E2level of HCG day,the oocyte and embryo parameters and pregnancy outcomes were compared between two groups.Results The number of oocytes,MII oocytes,good- quality embryos,the cycle cancellation rate in high responder group were significantly higher than those of normal responder group( P 0. 05),but the MII oocytes rate,fertilization rate,high- grade embryo rate and implantation rate were significantly lower than those of normal responder group( P 0.05). No significant difference in cleavage rate,pregnancy rate,miscarriage rates and the incidence of moderate and severe ovarian hyperstimulation were found between two groups( P 0. 05). Conclusion The high ovarian response would affect the quality of oocyte and embryo,pregnancy outcome though high estrogen environment.