[Influence of EmbryoGlue on the implantation of embryo and pregnancy outcome in vitro fertilization-embryo transfer].

OBJECTIVE: To study the influence of EmbryoGlue on the implantation of embryo and pregnancy outcome in vitro fertilization (IVF)-embryo transfer (ET). METHODS: From August 2010 to January 2011, 243 infertile patients in Reproductive Medical Center of Tianjin Medical University General Hospital who underwent IVF or intracytoplasmic sperm injection (ICSI) were divided into two groups, including 129 cases used EmbryoGlue as the embryo transfer medium in experimental group and 114 cases used G-2 as embryo transfer medium in control group. Pregnancy outcome were compared between two groups. RESULTS: (1) The female age, IVF/ICSI constituent ratio, previous failure cycles and infertile factors of patients did not show statistical difference between experimental group and control group (P > 0.05). (2) The implantation rate of women in experimental group increased significantly compared with the control group [30.4% (85/280) vs. 18.8% (48/255), P < 0.05]; Clinical pregnancy rate increased significantly compared with the control group [48.8% (63/129) vs.34.2%(39/114), P < 0.05]; Multiple pregnancy rate increased significantly compared with the control group [34.9% (22/63) vs. 20.5% (8/39), P < 0.05]; Ectopic pregnancy rate decreased significantly compared with the control group [4.8% (3/63) vs. 17.9% (7/39), P < 0.05]. CONCLUSION: EmbryoGlue can facilitate embryo implantation in IVF-ET and reduce the occurrence of ectopic pregnancy.