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2010•Chinese Journal of MisdiagnosticsRequires access

Expression of Ang-4 Protein and Its Relationship with Microvessel Density in Colorectal Adenocarcinoma

Bing Wu

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Abstract

Objective To examine the expression of Ang-4 protein in colorectal adenocarcinoma and its relationship with microvessel density.Methods Immunohistochemistry technique was used to assess the expression levels of Ang-4 and CD34 in 48 cases of colorectal adenocarcinoma and 25 cases of normal colon tissues respectively.The microvessel density(MVD) was counted by the expression of CD34.Results The expression of Ang-4 protein in colorectal adenocarcinoma was significantly higher than that in normal colon tissues(75.0% vs 20.0%,P0.001).There was a remarkable positive correlation between the expression of Ang-4 and MVD in colorectal adenocarcinoma(r=0.577,P0.01).Conclusion The overexpression of Ang-4 protein may play an important role in angiogenesis of colorectal adenocarcinoma and may promote the development of it.

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What this paper is about

Objective To examine the expression of Ang-4 protein in colorectal adenocarcinoma and its relationship with microvessel density.Methods Immunohistochemistry technique was used to assess the expression levels of Ang-4 and CD34 in 48 cases of colorectal adenocarcinoma and 25 cases of normal colon tissues respectively.The microvessel density(MVD) was counted by the expression of CD34.Results The expression of Ang-4 protein in colorectal adenocarcinoma was significantly higher than that in normal colon tissues(75.0% vs 20.0%,P0.001).There was a remarkable positive correlation between the expression of Ang-4 and MVD in colorectal adenocarcinoma(r=0.577,P0.01).Conclusion The overexpression of Ang-4 protein may play an important role in angiogenesis of colorectal adenocarcinoma and may promote the development of it.

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Available abstract

Objective To examine the expression of Ang-4 protein in colorectal adenocarcinoma and its relationship with microvessel density.Methods Immunohistochemistry technique was used to assess the expression levels of Ang-4 and CD34 in 48 cases of colorectal adenocarcinoma and 25 cases of normal colon tissues respectively.The microvessel density(MVD) was counted by the expression of CD34.Results The expression of Ang-4 protein in colorectal adenocarcinoma was significantly higher than that in normal colon tissues(75.0% vs 20.0%,P0.001).There was a remarkable positive correlation between the expression of Ang-4 and MVD in colorectal adenocarcinoma(r=0.577,P0.01).Conclusion The overexpression of Ang-4 protein may play an important role in angiogenesis of colorectal adenocarcinoma and may promote the development of it.

Key concepts: Colorectal adenocarcinoma, Immunohistochemistry, Medicine, Adenocarcinoma, Microvessel, CD34, Angiogenesis, Colorectal cancer

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Expression of Ang-4 Protein and Its Relationship with Microvessel Density in Colorectal Adenocarcinoma — Research Paper | ScholarLens