Expression of Ang-4 protein on colorectal adenocarcinoma and its clinipathological significance

【Objective】To investigate the correlation of Ang-4 protein expression on colorectal adenocarcinoma with its Clincopathological parameters. 【Methods】Immunohistochemistry technique was used to assess the expression levels Ang-4 protein in 45 cases of colorectal adenocarcinoma and 20 cases of normal colon tissues respectively.Its Clinipathological relation was analysised by SPSS 10.0 for Windows software. 【Results】The expression rate of Ang -4 protein in colorectal adenocarcinoma was significantly higher than that in normal colon tissues (75.6% vs 20.0%,P0.001). No correlations were found between the expression level of Ang-4 and the size ,invasion ability . The expression rate of Ang-4 protein was significantly correlated with the histological differentiation, lymph node metastasis and TNM staging.【Conclusion】The overexpression of Ang-4 protein may play an important role in angiogenesis of colorectal adenocarcinoma.It may be regarded as an index for prognosis in colorectal adenocarcinoma.