Effects of combination therapy with lamivudine on HBV-related early liver cirrhosis

[Objective] To investigate effect of combination therapy with Lamivudine on HBV-related early liver cirrhosis.[Methods]67 cases with HBV-related early liver cirrhosis were divided into group A(n=32)and group B(n=35).There was no difference between 2 groups at baseline data(P0.05).Patients in group A received lamivudine 100mg once daily for one year.Patients in group B received lamivudine 100mg once daily,and Shu Gan Ying Wan,9 g,and Gan An San,3.5 g,3 times daily for one year.Virological response and biochemical response were observed.[Results]Similar good virological responses were seen in both groups.Good Biochemical responses were observed in both groups after one year treatment,and the improvement in group B was much better than in group A,particularly for albumin level(P0.01).[Conclusions]Combination therapy with lamivudine is more efficacy on HBV-related early cirrhosis,particularly in biochemical improvement.