Synthesis of coumarin-3-ethyl formate under microwave irradiation
Lin Zhang-shou
Abstract
Lin Zhang-shou
Abstract
Coumarin-3-ethyl formate was synthesized by salicylaldehyde and diethyl malonate under mi- crowave irradiation.The product was characterized through ~1H NMR and IR.The factors,which affect the reac- tion,were investigated and optimized.Under the optimum reaction conditions,the rate of reaction was up to 20 times faster than by conventional method,and the yield was 86.1%.
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Coumarin-3-ethyl formate was synthesized by salicylaldehyde and diethyl malonate under mi- crowave irradiation.The product was characterized through ~1H NMR and IR.The factors,which affect the reac- tion,were investigated and optimized.Under the optimum reaction conditions,the rate of reaction was up to 20 times faster than by conventional method,and the yield was 86.1%.
Key concepts: Ethyl formate, Coumarin, Formate, Yield (engineering), Salicylaldehyde, Diethyl malonate, Chemistry, Microwave irradiation