The Observation of the Clinical Effect of the Application of Adefovir Dipivoxil in Patients with Chronic Hepatitis B

Objective To evaluate the clinical efficacy of adefovir in the treatment of chronic hepatitis B. Methods 105 cases of chronic hepatitis B patients in our hospital from November 2009 to January 2013 period were randomly divided into two groups, the observation group of 58 cases was taken with oral adefovir dipivoxil tablets treatment and the control group was taken with conventional liver reduced enzyme medication. The HBV-DNA negative rate, HBeAg/HBeAb seroconversion, ALT normalization rates, and changes in liver fibrosis after 48 weeks for the two groups were compared. Results The HBVDNA negative rate, HBeAg/HBeAb seroconversion and ALT normalization ratesin the observation group were higher than the control group(P0.05). After treatment, the degree of decreasing liver fibrosis in the observation group was better than the control group(P0.05). Conclusion Adefovir dipivoxil in the time of anti-hepatitis B virus in chronic hepatitis B patients delay the occurrence of liver fibrosis, and it has long-term prognosis positive significance on significance for chronic hepatitis B patients.