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Comparing the Distribution of Genetic Polymorphism of MTHFR Thermolabile between Mongolian Population and Hans of China

Pei Li

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Abstract

The purpose of this study is to compare the genetic polymorphism distribution of the 677th nucleotide of MTHFR between the Mongolian population and the Hans of China,and to obtain the population genetic data of this polymorphism.Using PCR-RFLP method,the authors analyzed the genotypes of the 677th nucleotide of MTHFR in Mongolians and Hans.Results show that in Mongolian population,the proportion of wild type is 45.6%,proportion of heterozygotes is 39.2% and that of homozygotes is 15.2%; While in Hans,proportions are wild type 17.9%,heterozygotes 55.7% and homozygotes 26.4%.The ratios of genotypes are significantly different between Mongolian and Han populations(χ2-test,P0.001).The 677th allele frequency in Mongolians is 34.8%,lower than that in Hans(54.2%,u-test,P0.001).This suggests that the mutant MTHFR gene frequency is significantly higher in the Han population than in the Mongolian population in China.

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What this paper is about

The purpose of this study is to compare the genetic polymorphism distribution of the 677th nucleotide of MTHFR between the Mongolian population and the Hans of China,and to obtain the population genetic data of this polymorphism.Using PCR-RFLP method,the authors analyzed the genotypes of the 677th nucleotide of MTHFR in Mongolians and Hans.Results show that in Mongolian population,the proportion of wild type is 45.6%,proportion of heterozygotes is 39.2% and that of homozygotes is 15.2%; While in Hans,proportions are wild type 17.9%,heterozygotes 55.7% and homozygotes 26.4%.The ratios of genotypes are significantly different between Mongolian and Han populations(χ2-test,P0.001).The 677th allele frequency in Mongolians is 34.8%,lower than that in Hans(54.2%,u-test,P0.001).This suggests that the mutant MTHFR gene frequency is significantly higher in the Han population than in the Mongolian population in China.

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Available abstract

The purpose of this study is to compare the genetic polymorphism distribution of the 677th nucleotide of MTHFR between the Mongolian population and the Hans of China,and to obtain the population genetic data of this polymorphism.Using PCR-RFLP method,the authors analyzed the genotypes of the 677th nucleotide of MTHFR in Mongolians and Hans.Results show that in Mongolian population,the proportion of wild type is 45.6%,proportion of heterozygotes is 39.2% and that of homozygotes is 15.2%; While in Hans,proportions are wild type 17.9%,heterozygotes 55.7% and homozygotes 26.4%.The ratios of genotypes are significantly different between Mongolian and Han populations(χ2-test,P0.001).The 677th allele frequency in Mongolians is 34.8%,lower than that in Hans(54.2%,u-test,P0.001).This suggests that the mutant MTHFR gene frequency is significantly higher in the Han population than in the Mongolian population in China.

Key concepts: Methylenetetrahydrofolate reductase, Genetics, Genotype, Thermolabile, Allele, Biology, Population, Single-nucleotide polymorphism

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