Polymorphism of CX3CR1 in healthy people of Han in province of Hunan

Objective:To investigate the Polymorphism of CX3CR1 in healthy people of han in province of hunan as well as the difference in the distribution of genetic polymorphism between han in hunan province and other populations. Methods:The polymorphisms of CX3CR1 in 150 healthy han population were analyzed by multiplex polymerase chain reaction- restriction fragment length based (PCR-RFLB). The genetype and allelic frequencies were calculated and compared with those in other populations.Results:V249I and T280M were detected in han population.Two genetypes have been detected in V249I .VV was the most common genetype,with the frequency of 88%,he frequency of VI was 12%,no II genetype was detected.the frequency of V allele and I allele was 94% and 6% for separate.T280 allele and M280 allele were detected in population. TT was the most common genetype,with the frequency of 95.3%,he frequency of VI was 4.7%,noMM genetype was detected.The frequency of T allele and M allele was 97.7% and 2.3% for separate.Conclusions:There is significant difference in the distribution of CX3CR1 between han population in hunan province and Uygur population as well as European population,the distribution of CX3CR1 Polymorphism of Han population in province is similar to those of Han population in xinjiang Uygur autonomous region,Chinese Dai population,Chingpaw population and Japanese population.